The Workpackages for TOLERAGE are grouped into four thematic areas:
|
Workpackage Area 1 - Mechanisms of central and peripheral tolerance
|
||
| WP1 | T-cell selection: The role of intrathymic autoantigen expression | |
| WP2 | Thymic involution: The role of locally produced glucocorticoid hormones | |
| WP3 | Teffector/Tregulatory imbalance with increasing age | |
| WP4 | The role of dendritic cells in tolerance induction | |
| WP5 | The role of dendritic cells in antigen presentation | |
| WP6 | Generation of regulatory dendritic cells in vitro using glucocorticoid hormones | |
| WP7 | Age dependent changes of the cytokine balance | |
|
Workpackage Area 2 - Paradigmatic diseases of aging - rheumatoid arthritis and atherosclerosis
|
||
| WP8 | Rheumatoid arthritis | |
| WP9 | Atherosclerosis | |
|
Workpackage Area 3 - Therapy by induced tolerance
|
||
| WP10 | Induction of immunologic tolerisation to autoantigens | |
| WP11 | Mechanisms of tolerance induction | |
| WP12 | Manipulation of locally produced glucocorticoids to delay thymic involution as therapy in models for autoimmunity | |
|
Workpackage Area 4 - Management
|
||
| WP13 | Management | |